Abstract

SYNTHESIS AND EVALUATION STUDY OF ANTIOXIDANT ACTIVITIES OF CHALCONES AND THEIR DERIVATIVE

Kalika H. Durg*, Prabhudev S. M., Hanamanth J. K. and Kishore Singh C.

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Abstract

Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity and good pharmacological actions. In this study we’re specifically focusing on the the anti-oxidant activity of chalcone by Synthesizing a suitable chalcone derivative moiety and evaluating for in-vitro anti- Oxidant activity by DPPH Assay and Spectral Studies such as FTIR and UV Spectroscopy. Furthermore, the role and contribution of different functional groups on the antioxidant activity of the synthesized chalcone derivatives are also probed and rationalized in terms of their electronic and structural effect.

Keywords: Chalcones, anti-oxidant activity, DPPH Assay.