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Abstract

FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM ORODISPERSIBLE TABLET USING NOVEL COPROCESSING METHOD

Nitesh Nagar*, Umesh K. Atneriya, Umashankar Joshi and Dharmendra Solanki

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Abstract

The oral route of administration is considered as the most widely accepted route. Oral dosage forms dissolve rapidly in saliva and can be swallowed without the need of drinking water Oro-Dispersible tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. Losartan Potassium is an angiotensin II receptor antagonist. It suppresses the effects of angiotensin II at its receptors, thereby blocking the rennin-angiotensin system. The rennin-angiotensin system plays a crucial role in the control of blood pressure & thus plays an important role in hypertension. Losartan potassium has been selected as a model drug to study the effect of co-processed superdisintegrants by formulating it as an ODT. Co-Processing is defined as combining two or more excipients by an appropriate process. Co-Processing of excipients could lead to formation of excipients with superior properties compared with the simple physical mixture of their components or with individual components like improved flow properties, improved compressibility, better dilution potential, fill weight uniformity, low/no moisture sensitivity, reduced lubricant sensitivity & good machine ability even in high speed tableting machinery with reduced dwell times. The low bioavailability would increase as the drug is directly taken in systemic circulation & first pass metabolism is avoided & formulating it as an ODT causes rapid dissolution of drug & absorption, which may produce the rapid onset of action in the treatment of hypertension. Our aim is to prepare ODT of this drug and avoid the complications occurring with conventional system. The proposed work is envisaged to carry out the preformulation, optimization, development of co-processed excipients and then formulation and evaluation of ODT.

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