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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

DESIGN, SYNTHESIS AND ANTICANCER ACTIVITY OF SUBSTITUTED BENZOXAZOLE DERIVATIVES

Chetan K.*, Prabhudev S. M., H. J. Kallur and Laxmisagar

Abstract

Benzoxazole and azetidinone are the most important heterocycles exhibiting remarkable anticancer activities. A series of Benzoxazole substituted azetidinone derivatives were synthesized, characterized and evaluated for the anticancer study. The structures were confirmed by 1H NMR, 13C NMR and MASS spectral techniques. The docking studies of synthesized compounds were done to find the binding activity of the derivatives to the VEGFR-2 receptors.

Keywords: Benzoxazole, Azetidinone, Anticancer activity.

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