Abstract

A CASE STUDY ON PAUCI IMMUNE GLOMERULONEPHRITIS

Ganeshakumara M., K. Bhavani, Praveenkumar K., H. P. Sahana, Jahnavi G. and Dr. Nagarjuna D.*

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Abstract

Rapidly progressive glomerulonephritis (RPGN) is a syndrome signified by a precipitous loss of renal function, with features of glomerulonephritis including dysmorphic erythrocyturia and glomerular proteinuria. The immune system and the kidneys are closely linked, and chronic kidney disease (CKD) often results from various auto(immune) disorders. This is a case report of Pauci immune glomerulonephritis also called as RPGN (rapidly progressive glomerulonephritis) of which 35 year female patient was admitted in hospital with illness of fever and cough, her past medical history conveys that she is not a known case of hypertension and diabetes mellitus and she doesn’t have any habits. On physical examination her BP was found to be 110/70 mm of hg and pulse rate was 90 beats per minute. On systemic examination diagnosis done with RFT, CBC, Direct immunofluorescence And Histopathology Report, Vasculitis Profile. based on these reports the diagnosis is confirmed as Pauci immune glomerulonephritis and vasculitis associated with ANCA. Treatment is started by giving anticancer drug like Endoxan, methyl prednisolone, IFA, Folvite and Sodium bicarbonate and supplements. Physician followed the guidelines for the treatment of pauci immune glomerulonephritis, prescribing anticancer drug can helps to prevent the active crescent’s with mitotic activity, and prescribing the corticosteroids and immune suppressants can helps to treat the inflammation and over activity of immune system can helps to reduce the patient severity. To increase the life expectancy of patient by giving suitable treatment and advising to maintain self hygiene and Diet.

Keywords: Pauci immune glomerulonephritis, Rapidly progressive glomerulonephritis, Vasculitis associated with ANCA (Anti neutrophil cytoplasmic antibody), Chronic kidney disease (CKD).