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Abstract

MICROWAVE ASSISTED SYNTHESIS VIA CHALCONES, CHARACTERIZATION AND ANTHELMINTIC SCREENING OF PYRIMIDINE DERIVATIVES

Neelambika*, Hanamanth J. K., Prabhudev S. M. and Kishore Singh C.

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Abstract

Chalcones possess a broad spectrum of biological activities including antioxidative, antibacterial, antihelmintic, amoebicidal, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, cytotoxic and immunosuppressive. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity and good pharmacological actions. In the present study, we focused on the environment-friendly processes used for the preparation of pyrimidine derivatives with pharmacological properties. In this regard, microwave heating is used as the alternative energy sources to synthesize a series of pyrimidine derivatives by the condensation of chalcones with urea under basic conditions. Chalcones were synthesized by Claisen -Schimidt condensation of acetophenone with various substituted benzaldehyde in the presence of ethanolic potassium hydroxide solution. The synthesized pyrimidine derivatives were characterized by IR, 1H NMR, Mass Spectra and CHN analyses confirmed the structure of the prepared compounds. The newly synthesized pyrimidine derivatives were screened for their antimicrobial & anthelmintic activity.

Keywords: Pyrimidine, Chalcone, Anthelmintic activity.


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