Abstract

NANOSPONGES: A POTENTIAL NANOCARRIER FOR TARGETED DRUG DELIVERY

Baburao A. Bachkar*, Laxmikant T. Gadhe, Pratik Battase, Nirmal Mahajan and Rahul Wagh, Swati talele, Dr.G.N.Chaudhari

Abstract

The ideal delivery systems solubilize the drug, lead the therapy to the target site to fulfill the individual need of the patient and disease stage. Effective targeted drug delivery to specific sites is the significant problem which is being faced by the researchers. Nanosponges are such of effective drug carrier which overcome these problems. It is a versatile drug delivery system as they can load both hydrophilic and hydrophobic drugs and also conquer the problem of drug toxicity and poor bioavailability. Nanosponges are solid, porous, biocompatible, tiny in size with three dimensional structure and nanomeric cavity size which have unique ability to entrap wide variety of drugs. Nanosponges can be used as a carrier for biocatalysts in the delivery and release of enzymes, proteins, vaccines and antibodies. Nanosponges has various applications like enhancing bioavailability of drugs and delivery of drugs into oral, topical as well as parenteral routes.

Keywords: Nanosponges, Controlled release, Targeted release, Colloidal sizes.