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Abstract

FORMULATION AND EVALUATION OF BISOPROLOL FAST DISSOLVING TABLETS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman and Mohammed A. Al khawlani

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Abstract

Bisoprolol Fumarate is a cardio selective β-blocker which is used for the treatment of stable chronic heart failure with reduced systolic left ventricular function in addition to ACE inhibitors, diuretics, and optionally cardiac glycosides. The presently preferred route of administration for Bisoprolol Fumarate is oral. Bisoprolol was chosen to be the active pharmaceutical ingredient (API) in a fast-dissolving tablets FDTs formulation, being a model of fast dissolving tablets of Bisoprolol Fumarate, an antihypertensive agent. The present study was aimed to formulate, evaluate and optimized a tablet which disintegrates and fast dissolving to show a rapid onset of action. In the present study, attempt has been made to prepare FDTs of Bisoprolol using superdisintegrants like croscarmellose sodium, and crospovidone in different ratios by direct compression. The prepared batches of tablets were evaluated for weight variation, hardness, friability, disintegration time, wetting time and in-vitro drug release which tested. Among the all formulations F2 formulation was found to be showed improved drug release characteristics. F2, which consists of (Bisoprolol, mannitol, avicel PH101, crospovidone, aspartame, aerosil, talc, magnesium stearate), showed the best result in drug disintegrated time, faster dissolution rates and higher efficiency values.

Keywords: Bisoprolol, Fast dissolving tablets, Antihypertensive agent, Superdisintigrants, Formulations.


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