Abstract

EFFICACY (IN TERMS OF OVULATION INDUCTION) OF CLOMIPHENE CITRATE AND LETROZOLE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: RANDOMIZED CONTROL TRIAL STUDY

Rabia Iram*, Sidrah Ali, Sabira and Momy Gul

Abstract

Background: Among the usual endocrine abnormalities in women of childbearing age is polycystic ovary syndrome (PCOS). Despite being the dominant source of infertility, its causes still remained unknown as well as its effective treatment. Nevertheless, through adequate diagnosis and treatment, majority of the symptoms of PCOS either can be controlled or eliminated. Objective: To compare the efficacy (in terms of ovulation induction) of clomiphene citrate and letrozole in women with polycystic ovarian syndrome. Settings & Duration of study: Department of Gynaecology and Obstetrics, Sandeman Provincial Hospital, Quetta. This randomized control trial study was from 1/10/2018 to 1/4/2019. Methods: A total of 84 patient was offered to pick up a slip from total mixed up slips and respondents was placed in that respective group according to their chosen slip. In group A, Letrozole 5.0 mg daily from Day 5 to Day 9 of menstruation was given while in group B patients, clomiphene citrate 100 mg daily from Day 5 to Day 9 of menses were given. All patients in both groups were evaluated by the researcher herself and efficacy (as per-operational definition) were noted on 5th day of menses. Results: The mean age in Group A was 32 years with SD ± 8.77 while mean age in Group B was 34 years with SD ± 7.12. in Clomiphene citrate was effective in 60% patients and was not effective in 40% patients, whereas Group B was effective in 80% patients and was not effective in 20% patients. Conclusion: Our study concludes that Letrozole is more efficient drug for ovulation induction in women with polycystic ovarian syndrome as compared to clomiphene citrate.

Keywords: Ovulation induction, Clomiphene citrate, Efficacy, Letrozole, Polycystic ovarian syndrome.