Abstract

PREPARATION AND FORMULATION OF TOPICAL PRONIOSOMAL GEL OF AN ANTI-INFLAMMATORY DRUG FERULIC ACID

Sunil Kumar* and Dr. Abhishek Soni, Dr. Dev Prakash Dahiya and Dr. Chinu Kumari

Abstract

Ferulic acid is a derivative of hydroxyl cinnamic acid and is abundant in foods, fruits and beverages. Many studies have proven the effectiveness of this compound as an antioxidant, anti-inflammatory and antimicrobial agent. The utilization of this compound is however limited due to its low water solubility. A vesicular drug delivery system called niosome may be a solution to improve the deficiencies of TFA. To this end, a simple film hydration method was employed to prepare noisomes. Niosomal formulations were designed according to the Central Composite Design (CCD). Several niosomal formulations were prepared with the optimized formulation having an EE% and mean particle size of 21.64% and 158.7 nm respectively. The in vitro percutaneous absorption showed that 88.2 ± 4.90% of the niosomal formulation accumulated in the viable layers, ~1.4 ± 0.3% in the receiver fluid and only 9.7 ± 5.2% of the drug in the stratum corneum. The ATR-FTIR results ruled out any chemical interactions between the drug and other components of the formulations. A carrageenan-induced rat paw oedema test was performed for the evaluation of anti-inflammatory effects. The results showed that the optimized niosome gel of inhibited the oedema about 21.37 ± 4.17% which was also confirmed by the histopathology images. Objective: To fight off free radicals, which play a role in age related skin issues, including age spots and wrinkles. Methods: Slurry, spray coating, coacervation phase sepration method.

Keywords: Anti-inflammatory, antioxidant, antimicrobial, anticancer, cross-linking agent.