Abstract

ANTI DIABETIC POTENTIAL OF FLAVONOIDS ON ALLOXAN INDUCED DIABETIC RATS

Pushpa Simaiya*, Salaj Khare, Sunil Kumar Shah and Neelmani Chauhan

Abstract

Objective: Diabetes mellitus is one of the world's most significant health issues, with rising prevalence and related mortality. The diabetes is increasing steadily, making it a global public heath problem. Inadequate blood sugar control has important health implications. The use of flavonoids in treating various diseases. Diabetic metabolic abnormalities can be regulated by the efficiency of these flavonoids. Method: Rats received standard rodent chow and water ad labium. Rats were acclimatized to laboratory conditions for 7 days before carrying out the experiments. All the experiments were carried in a noise free room between 08.00 to 15.00 h. Separate group (n=6) of rats was used for each set of experiments. Result: Diabetes mellitus is the most common endocrinological disorder which is characterized by metabolic abnormalities and long term complications. This has prompted an expanding interest for common items with anti diabetic action and fever reactions. From writing audit it was found that numerous herbs and plant items have been appeared to have hypoglycemic activity. Flavonoids are known not bioactive anti diabetic standards. Alloxan is a beta cytotoxin which in cites "compound diabetes" in a wide assortment of creature species by harming the insulin emitting pancreatic– cell. Conclusion: In conclusion, taking everything into account, the present examination uncovered that the blood glucose bringing down action of flavonoid -Boswellic corrosive might be by invigorating β-cells to discharge more insulin.

Keywords: Anti-diabetic activity, flavonoids, Boswellic acid, alloxan.