Abstract

DEVELOPMENT, OPTIMISATION AND CHARACTERIZATION OF DEEP EUTECTIC SYSTEM TO ENHANCE ORAL BIOAVAILABILITY OF CEFUROXIME AXETIL

Dr. Abhishek Soni, Dr. Rajender Gulria, Dr. Dev Prakash Dahiya, Dr. Chinu Kumari, Vinay Thakur*

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Abstract

Objective: In the present research work, the dissolution of the cefuroxime axetil was enhanced by using the deep eutectic solvent mixture and also improved the solubility of cefuroxime axetil. Methods: Fourteen formulations were prepared (CCDES1-14). Result and Discussion: The dissolution of the cefuroxime axetil was enhanced by using of the deep eutectic solvent mixture. The melting point range for cefuroxime axetil was 200.66°C±0.57-205.66°C±1.52. The standards calibration curve showed a linear connection between concentration and absorbance with a linear equation of Y=0.0453x- 0.0017 and a linear coefficient of 0.999. In the FT-IR spectra of pure CA, two separate absorption bands were observed at 3313.71cm-1 and 3190.68 cm-1 for N–H stretching (primary amide), and C=O stretching of β-lactam, carbamyl and amide groups was observed at 1761.47 and 1678.97 cm-1 and 1532.37 cm-1, respectively. The drug peak in the deep eutectic mixed solvent formulation CCDES14 was not seen with reduced intensity. Conclusion: The dissolution of the cefuroxime axetil was successfully enhanced by using of the deep eutectic solvent mixture.

Keywords: Dissolution, cefuroxime axetil, deep eutectic solvent mixture.