Abstract

ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF VITEX NEGUNDO LINN. AND VITEX TRIFOLIA LINN. LEAVES ON EXPERIMENTAL ANIMAL

Julie Tomar, Megha Jain*, Vipin Sharma, Naveen Sharma and Vinay Jain

Abstract

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, its stiffness and loss of joint function. The present study was conducted to comparative anti-inflammatory study of ethanolic extract of Vitex Negundo Linn., Vitex Trifolia Linn. leaves and diclofenac sodium in Carragenan-induced paw edema model Albino Wistar rats. A significant inhibition of carragenan induced rat paw edema comparable to that produced by Diclofenac sodium, the standard anti inflammatory drug. Test extracts was obtained by shoxelation method of extraction of both of the plant leaves with ethanol, tested in the present study. The results from present study indicate the efficacy of the ethanolic extract of Vitex Negundo Linn., Vitex Trifolia Linn. as a therapeutic agent in inflammatory conditions. Thus it could be concluded that Vitex Negundo Linn. and Vitex Trifolia Linn. leaves extracts possess significant anti-inflammatory properties. A better effect was observed with Vitex Negundo Linn. because it effectively reduce the paw edema in Carragenan-induced paw edema model Albino Wistar rats.

Keywords: Anti inflammatory activity, Vitex Negundo Linn., Vitex Trifolia Linn., Carragenan-induced paw edema, Diclofenac sodium.