Abstract

DESIGN AND IN-VITRO CHARACTERIZATION OF TERAZOSIN ORAL DISPERSIBLE TABLETS BY USING VARIOUS SUPERDISINTEGRANTS

Atla Vijaya Bhargavi*, Angilicam Avinash and V. Leela Lakshmi

Abstract

Terazosin is a medication used to treat symptoms of an enlarged prostate and high blood pressure. For high blood pressure, it is a less preferred option. It is taken by mouth. In the present work Croscarmellose sodium, Sodium starch glycolate and Crospovidone were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F5 formulation showed maximum % drug release i.e., 98.73 % in 10 min hence it is considered as optimized formulation. The F5 formulation contains Sodium starch glycolate as super disintegrate in the concentration of 20 mg.

Keywords: Terazosin, Croscarmellose sodium, Crospovidone and Sodium starch glycolate.