Abstract

FORMULATION AND INVITRO EVALUATION OF TEMAZEPAM TABLETS FOR SUBLINGUAL DRUG DELIVERY SYSTEM

Navakoti Preethi* and Dr. M. Krishnaveni

Abstract

Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action. In the present work temazepam sublingual tablets using Locust bean gum, Croscarmellose sodium and Crospovidone as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F3 formulation showed maximum % drug release i.e., 98.13% in 8 min hence it is considered as optimized formulation. The F3 formulation contains Locust bean gum as super disintegrate in the concentration of 30 mg.

Keywords: Temazepam, sublingual tablets, Croscarmellose sodium, Locust bean gum and Crospovidone.