Abstract

PREPARATION AND EVALUATION OF PRELIMINARY BUCCAL FILMS USING SAGO STARCH AND HPMC E15 POLYMERS

Mohammad Amisha Sulthana*, Krishnaveni Manubolu and K. Harinadha Baba

Abstract

The main aim of this work is to design mucoadhesive buccal films using natural and semi-synthetic polymers such as Sago Starch and Hydroxy Propyl Methyl Cellulose (HPMC E15). The mucoadhesive buccal films were prepared using the solvent casting method. The natural polymer and semi-synthetic polymer are used in the preparation of blank buccal films as they are biocompatible, biodegradable, non-toxic and safe to use. The blank films were prepared to understand the physicochemical characteristics of the different polymeric films before formulating drug-loaded films. The prepared buccal films were studied for physicochemical properties and various evaluation parameters such as thickness, folding endurance, weight variation, swelling index, and statistical analysis. The blank buccal films show good physicochemical properties and evaluation parameters were in acceptable range. These preliminary results indicate that polymeric films can represent a valid vehicle for the buccal delivery of drugs.

Keywords: HPMC E15, Sago Starch, Blank Buccal films, Buccal Drug Delivery, fast-pass metabolism.