Abstract

PREPARATION AND EVALUATION OF PRELIMINARY MICROSPHERES USING PECTIN AND XANTHAN GUM POLYMERS

B. Binathi*, Krishnaveni Manubolu and Dr. K. Harinadha Baba

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Abstract

This work is aimed to design blank microspheres using natural polymers such as pectin, and xanthan gum in order to achieve controlled release. The microspheres were Prepared by ionotropic gelation method using different ratios of sodium alginate-pectin, and sodium alginate-xanthan gum polymers. The blank microspheres were prepared to understand the morphological characteristics and physicochemical properties. Microspheres were subjected to different evaluation parameters such as morphology, percentage yield, flow properties are the angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio, particle size, and swelling index. The prepared microspheres are spherical in shape, and show good flow properties and pH-dependent swelling was seen, indicating that water intake was low in an acidic medium and elevated in an alkaline medium pH. The successful development of blank microspheres using natural polymers. These preliminary results indicate microspheres can represent a valid carrier for controlled drug delivery of drug.

Keywords: microspheres, pectin, xanthan gum, sodium alginate, and pH-dependent.