Abstract

A PHARMACOLOGICAL STUDY ON ACACIA NILOTICA EXTRACT FOR WOUND HEALING ACTIVITY ON MICE AND IT’S IN-VITRO ANTIBACTERIAL EFFECT ON PUS FORMAING BACTERIA

Priyanka Pandey* and Wasim Raja

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Abstract

Using excision wound models on albino mice, the current work tests the ability of gels made from Acacia nilotica leaf extract to cure wounds. A wound-healing ointment made from Acacia nilotica leaf methanolic extract (1 and 2%) was created and tested on albino mice. The extract formulations were made in separate carbopol gels as well as in combination in an equal ratio. When compared to a normal betadine wound healing ointment, treated animals displayed a much shorter period of epithelization and wound healing activity. The rich phytoconstituents included in methanolic extracts, which either have an additive or individual action to speed up the process of wound healing, may be the cause of their improved wound healing activity. According to measurements of wound contraction rate, tensile strength, increased DNA, collagen, and protein synthesis, as well as histological analysis, Acacia nilotica extract ointment demonstrated noticeable wound healing activity and considerably improved the period of epithelialization and wound contraction. Another trial found that persistent wounds are a significant clinical issue that cause significant morbidity and mortality. Microorganisms' importance and involvement in the healing process of wounds have been hotly contested for many years. While some specialists believe that the microbial density is crucial in forecasting how quickly wounds will heal and become infected, others believe that the sorts of bacteria are more significant. Together, the findings of this study show, for the first time, the healing and anti-microbiological effects of Acacia nilotica extract in the treatment of skin wounds, specifically on pus-forming bacteria.

Keywords: Acacia nilotica, Wound healing activity, epithelization, Pus Formation, Bacteria and Methanolic extract.