Abstract

TOPICAL PAIN RELIEVERS: EFFECTIVENESS AND ADHERENCE AMONG PATIENTS

Aditya Rajesh Jakhad*, Sonali Rajendra Shejole, Karan Sanjay Pawar and Prachi Rajendra Khairnar

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Abstract

Topical analgesics reduce pain by acting on nearby cellular components and/or sensory nerve endings when administered locally to the skin or to specific compartments. This method has low systemic drug levels, good tolerability, few drug interactions, and the ability to combine with oral formulations. In line with the advancement in our understanding of the mechanisms underlying pain, there has been an increased emphasis on the development of novel drug delivery systems to offer patients individualized treatments without compromising analgesic efficacy. While severe pain serves as a warning, and persistent pain is a syndrome that necessitates careful analgesic selection. long-term use of high bioavailability medicines. Such requirements are current challenges. pharmaceuticals seek to combat, enabling gradual distribution of the active ingredient, preserving steady plasma concentrations and a favourable safety profile. This review discusses contemporary research on topical formulations of the most popular painkillers, including NSAIDs, anaesthetics, and capsaicin. Another issue is patient compliance with medical care, particularly for persistently painful illnesses. As was mentioned here, it is well established that reducing the complexity of the treatment and pill load are effective ways to improve patient compliance. However, the function of topical presentations in comparison to conventional methods has not yet been well investigated and is therefore yet unknown.

Keywords: Pain, NSAID, Topical, Chronic, Therapeutics, Patient Compliance.