Abstract

A ONE POT MULTICOMPONANT SYNTHESIS OF NOVEL PYRAZOLO[3,4 B]PYRIDINE DERIVATIVES BY MICROWAVE IRRADIATION TECHNIQUES

Sunita A. Chaudhari (Patil)*, Vasant M. Patil, Jitendra P.Raut Sambhaji V. Patil, Madhukar N. Jachak

Abstract

Green reagents in multi-component reaction are of increasing importance in organic and medicinal chemistry. 5-Amino pyrazole 5 was synthesized by known literature method and utilized for the synthesis of target compounds. 5- Amino pyrazole 5 was transformed to pyrazolo pyridine derivatives 10 by cyclocondensing three fold mixture of 5-aminopyrazole 5, aroyl acetonitrile 9 and Het.aryl aldehydes 8 by using basic catalyst triethyl amine and ethanol as a solvent. Alternatively it was synthesized by microwave irradiation technique; If the same reaction mixture was irradiated in microwave oven without any catalyst and solvent we obtained same product with maximum yield. It was observed that the compound obtained by both the method is one and the same and this can be confirmed by taking TLC, m.p., mix m.p., IR, 1H NMR and elemental analysis. All synthesized compounds were characterized by spectral and analytical methods.

Keywords: Microwave irradiation technique, 5-amino pyrazole, one pot reaction and multicomponant reaction