Abstract

PHARMACOKINETIC STUDY IN OXIDIZED O-AMINOPHENOL AND ITS BYPRODUCT COMPOUNDS: AN ORGANIC POLLUTANT

Hemendra Tripathi, Nisha Mehra* and Monika Rani

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Abstract

Hazardous substances in environment generate toxicity in acute life of living beings. Pollutants are created by trash or run-off produced by the industries, Polluted water, air, and soil have an impact on not only human activities but crops and aquatic life also. Present study was done to demonstrate the pharmacokinetic analysis in o-aminophenol and byproduct compounds of oxidized o-aminophenol. In silico ADME/Tox and PASS prediction study was done on the oaminophenol and byproduct compounds to evaluate their toxicity level. LD50 value of these compounds gives affirmation for the safety of these compounds. Some of byproduct compound 11-H dibenzo [b,e] [1,4]dioxepin-11-one, Phthalic acid and Phenol-2,4-bis (1,1-dimethylethyl) are noncarcinogenic in nature. Mostly byproducts are non-mutagenic, non-cytotoxic and nonhepatotoxic in nature. o-aminophenol likely to have carcinogenic nature than the byproduct compounds. These compounds depict drug likeliness property could be better used in pharma industries for the drug synthesis.

Keywords: ADMET study, In silico, o-aminophenol, Organic pollutant, Pharmacokinetics.