Abstract

CEFTRIAXONE INDUCED CHOREOATHETOSIS

Stephy Rachel Thomas*, Vandana Mohan, Merin Elza Anil and Dr. E. T. Arun Thomas

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Abstract

Beta-lactam antibiotics are widely used for the treatment of various bacterial infections due to their broad spectrum of activity and favourable pharmacokinetic properties. In patients with impaired renal function, these antibiotics can lead to a range of neurological manifestations as a result of altered drug metabolism and pharmacokinetics. Here we present a case report of a 74-year-old woman with End stage Kidney disease who exhibited neurological symptoms after receiving intravenous ceftriaxone. It also underscores the importance of considering altered pharmacokinetics and potential neurological side effects when prescribing beta-lactam antibiotics in patients with impaired renal function. This case highlights the need to closely monitor patients for any neurological manifestations, particularly when using ceftriaxone, which has good central nervous system penetration and extended half-lives.

Keywords: Choreoathetosis, Ceftriaxone, End Stage Kidney Disease.