Abstract

FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF LABETALOL

Ganjaraboina Sai Mahesh, V. Jhansi Priya Marabathuni* and Naidu Narapusetty

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Abstract

The present investigation revealed that the coating of core tablet with 240 mg of HPMC K4M and top coating of PRT with floating layer containing 80 mg HPMC K100M and 25 mg sodium bicarbonate provided desired lag time required for chronotherapy of hypertension. The optimized formulation showed 6 h of pulsatile release lag time, 4.4 min floating lag time and greater than 14.3 h of floating time. In vitro drug release study showed 81.21% drug release in 0.1N HCL within 30 min, indicating burst release. From the experimental findings it can be concluded that floating pulsatile tablets of Labetalol can give efficient therapy by reducing dose and dosing frequency and provide chronotherapy for an effective management of morning surge of hypertension.

Keywords: pulsatile drug delivery, Floating delivery system, hypertension, swelling index, dissolution rate.