Abstract

QUALITY OF LIFE IN PATIENTS WITH TYPE 2 DIABETES AND ESTABLISHED CARDIOVASCULAR DISEASE OF METFORMIN AND SULFONYLUREA TREATMENT

Nikolay Krasimirov Kostadinov* and Tzvetelina Tzvetanova Totomirova

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Abstract

Diabetes has a great effect on the quality of life (QoL) of patients, especially in cases with co-morbidities. In Bulgaria, there is an increase in the prevalence of diabetes by 20.88% and assessment of QoL is of interest for the overall health assessment of the patients. The aim of our study is to investigate satisfaction and health-related QoL in individuals with type 2 diabetes and established cardiovascular complication. Our study includes 40 type 2 patients, 20 men at age of 54.6 ±9.6 years and 20 women at age of 63.1±10.5 years. All of them with cardiovascular complication diagnosed within 1 month. Diabetes duration in group is 9,0±5,6 years, BMI in group is 33,6±4.95 kg/m2, 35% of patients received metformin, 15% were on sulfanylureas 15% and 50% received sulfanylureas plus metformin. HbA1c was 8,5±0.7 and fasting glucose 10.6±3.9 mmol/l. We used an extended version of SF36 questionnaire. The study period is November 2022 – April 2023 30% of men and 20% of women rated general health is very good. 50% of men and 60% of women rated it as good. 20% of men and women rate it as weak. Compared to 1 year ago, 10% of men and none of women rate their health as much better now; 30% of men and 40% of women define it as the same; 50% of men and women think that their health is slightly worse; 10% of both genders believe that their health is much worse now. 10% of men and 20% of women do not experience difficulties as a result of the disease. Patients in both groups are reporting worsening of QoL (p

Keywords: Quality of life, Metformin, sulfonilurea, Diabetes mellitus, Cardiovascular disease.