Abstract

DESIGN, SYNTHESIS AND EVALUATION OF SOME NOVEL -{[(1HINDOL- 4-YL)OXY]METHYL}-5-PHENYL-1,3,4-OXADIAZOLE DERIVATIVES AS POTENTIAL ANTIOXIDANT AGENTS

Kumara Prasad S.A.*, Srinivasa U., Subrahmanyam E.V.S and Shabaraya A.R.

Abstract

A new series of 2-{[(1H-indol-4-yl)oxy]methyl}-5-phenyl-1,3,4- oxadiazole derivatives are synthesised by the reaction of 2-[(1H-indol- 4-yl)oxy]acetohydrazide (2) with different aromatic aldehydes to form schiff’s bases (3) and the cyclization of the 2-[(1H-indol-4-yl)oxy]-N'- benzylideneacetohydrazide (3) with chloramines-T a strong oxidizing agent to form the final compounds. Finally, the structures of all the various synthesized compounds were assigned on the basis of IR and 1H NMR spectral data and these compounds were screened for their antioxidant activity.

Keywords: 1,3,4-oxadiazole, Aromatic aldehyde, schiff’s base, Antioxidant activity.