Abstract

PROPARGYLAMINE MOIETY: A VERSATILE SCAFFOLD FOR DRUG DESIGN AND DISCOVERY

Ankireddy Aswani*, Bommana Pavani, Vardu Sravani and Yerva Jahnavi Reddy

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Abstract

The propargylamine moiety gained a lot of attention in the fields of medicinal chemistry and pharmaceuticals due to its wide range of applications stemming from its chemical reactivity and structural advantages. For many years scientists strategically designed, synthesized and evaluated propargylamine derivatives for various pharmacological activities. They have also developed strategies to understand the mechanism, activity, structure activity relationship of propargylamine moiety broadly. From the extensive research it is evident that the propargylamine derivatives exhibit diverse array of pharmacological properties including anti-cancer, anti-apoptotic, Mono Amino Oxidase-B (MAO-B) inhibitory activity, anti-microbial, antioxidant, and many more which make them potential candidates in the drug design. This versatility of propargylamine moiety makes it an incredible multi-target ligand for many diseases. This review provides an overview of reported compounds with propargylamine moiety, and their pharmacological actions as described in the literature. With more research propargylamine derivatives can find their place in potential drugs treating common ailments to life threatening conditions in the future.

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