Abstract

HEDGEHOG-GLI SIGNALING IN NEURODEGENERATION BY 3- NITRO PROPIONIC ACID INDUCED: NEUROGENESIS AND BEYOND

Susheela Kumari*, Palvi Sharma, Kiran Thakur, Shalini Chauhan and Pooja Sharma

.

Abstract

The hedgehog (Hh) pathway is one of a few that regulate the number and kind of cells generated during development in organisms ranging from Drosophila to humans. The hedgehog (SHH) signaling pathway is primarily convoluted in smooth muscle differentiation, adult tissue homeostasis, cell proliferation, tissue repair following injury, embryonic gut development, and tissue polarity during vertebrate and invertebrate development. A number of cellular and molecular pathways are involved in the process of reviving from neurodegeneration damage or injury. One of these is the Hedgehog pathway. The Hedgehog (Hh) signaling pathway is the most common signal transduction pathway in mammalian cells. The pathway has also been associated with several cancer as one of its component is PTCH Cause the Basal cell Nevus Syndrome. Aim: The aim of this review is about the involvement of hedgehog gli signaling in Neurodegeneration. Objective: The objective of this review is to know about the appliance and method of Involvement of hedgehog signaling in Neurodegeneration. In this commentary, we present data that there is the possibility of hedgehog – Gli signaling in Neurodegeneration induced by 3-NP. We Also briefly discuss about the various markers of Neurodegeneration.

Keywords: Neurodegeneration, Hedgehog-Gli, 3-Nitropropionic acid.