Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2-SUBSTITUTED BENZIMIDAZOLES

Dr. Kishor Singh Chhatrapati, *Ayesha C. Patel and Dr. Channamma G. M.

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Abstract

2-substituted benzimidazole was prepared from O-phenylenediamine and carboxylic acid in presence of 4N HCl, and reacting with 1-benzyl 2-substituted benzimidazoles the yield of different derivatives of benzimidazole. It is noteworthy that such a procedure for rapid preparation of various benzimidazoles affords advantages of short reaction time, moderate yield and simple workup. As expected, benzimidazole derivatives exhibited significant antimicrobial activity when compared with standard drugs. There is no such a thing as completely safe drug. Drugs are powerful tools, which alter physiological processes for the better or for the worse. A society that wishes to benefit from them will not achieve all the benefits open to it, if it ignores the fact and seeks for impossible standards or harmlessness.

Keywords: As expected, benzimidazole derivatives exhibited significant antimicrobial activity when compared with standard drugs.