Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF NIFEDIPINE NANOSPONGES FOR SOLUBILITY ENHANCEMENT

Mohammad Raza Khan*, Mayur Gokul Jayswal, Vasudev Sharma, Mansuri Toshib, Dr. Mohd. Rehan Deshmukh and Dr. G. J. Khan

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Abstract

The aim and objective of the present study was to formulate, optimize and evaluate Nifedipine Nanosponges for solubility enhancement and Polymeric Nanosponges delivery system was to deliver Nifedipine in a controlled manner. Nine Nifedipine Nanosponges formulations were prepared by emulsion solvent diffusion method by using polymer Ethyl cellulose and polyvinyl alcohol. The prepared Nanosponges formulation was evaluated for particle size and Polydispersity index, Production yield, Drug content, Drug Entrapment efficiency, In-vitro Drug release study and Stability studies. Particle size analysis showed that the average particle size of Nifedipine nanosponge using ethyl cellulose was found to be 249.6 nm with Poly Dispersity Index (PDI) value 0.352. Increased in the polymer concentration may increase their % production yield ranged from 65.15% to 85.36%. The drug content of all formulations was in the range of 78.79 %to 92.20%. and entrapment efficiency was in the range of 77.91% to 89.50%. The in-vitro drug release of optimized batch F2 showed the maximum drug release of 85.44% in 12 hrs and 90.86 in 24 hrs and Drug release in a controlled sustained manner and followed First order diffusion mechanism. Optimized Batch F2 formulation was subjected to stability studies for 3 months, it could be concluded that formulation was stable after 3-months stability study. Saturation solubility study was carried out, the result showed that increase in the solubility of Nifedipine as compare to the pure drug.

Keywords: Nifedipine, Nanosponges, Emulsion solvent diffusion method, Solubility, 32 Central composite design.