Abstract

AN EXPERIMENTAL EVALUATION OF THROMBOLYTIC ACTIVITY OF SHIGRU SEEDS (MORINGA OLEIFERA LAM) - AN IN-VITRO STUDY

Renita D’Souza*, Chandrakanth Bhat and Archana Kalluraya

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Abstract

Introduction: In the present era, due to unhealthy food and lifestyle people suffer from various life-threatening diseases. Thrombosis is one among such conditions which can suddenly cause blockage in blood vessels leading to Myocardial infarction, cerebrovascular thrombosis and deep vein thrombosis. Treatment of thrombosis involves administration of drugs that dissolve the blood clots. The thrombolytic drugs have limitations due to high risk of hemorrhage, severe anaphylactic reactions and lack of fibrin specificity. Hence, present study has been undertaken to discover the safest, reliable and efficient source for thrombolytic action. Aims and Objectives: To evaluate thrombolytic activity of Shigru seeds (Moringa oleifera Lam). Methodology: Evaluation of thrombolytic activity of Alcohol and Aqueous extract of Shigru seeds (Moringa oleifera Lam) was carried out on 180 blood samples of 30 healthy volunteers selected randomly, where Streptokinase is taken as positive control and Distilled water as negative control. Result: Thrombolytic experiment was conducted in 6 groups among which remarkable clot lysis was shown in aqueous extract group of Shigru seeds (Moringa oleifera Lam). It showed similar clot lysis to that of standard Streptokinase group. Interpretation and Conclusion: The result suggests that aqueous extract of Shigru seeds shows significant thrombolytic activity compared to Streptokinase ≥3500 I.U.

Keywords: Shigru seeds (Moringa oleifera Lam), Thrombolytic, Aqueous extract, Alcohol extract.