Abstract

FORMULATION AND EVALUATION OF FACE SERUM CONTAIN PHYTOSOME OF GINGEROL OIL, CARICA PAPAYA PULP EXTRACT AND ALOE VERA GEL

Mohini Patidar*, Nitin Deshmukh, Nilesh Mandloi, Bhoopendra Patidar, Lokesh Solanki and Dr. Sujit Pillai

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Abstract

The aim of the current study is to development, evaluation and application of phytosomes of gingerol oil, Carica papaya pulp extract, and aloe vera gel extracts in face serum formulations. The freshly cut ginger rhizome was meticulously extracted with water using the distillation technique and Carica papaya pulp with methanol:water (1:4) ratio through maceration method. Qualitative phytochemical screening detects the presence of flavonoids, terpenoids, phenol, phytosterol, and ascorbic acid in both the herbal plant extract. The phytosomes of Gingerol oil and Cariya papaya were made by mixing it in a 1:1 molar ratio with soy lecithin, and in a 1:2 molar ratio with phosphatidyl choline in ethanol respectively. Face serum composition formula includes aloe vera gel, Carica papaya phytosome, Gingerol phytosome carbomer 934, honey, isopropyl palmitate, EDTA and other ingredients. All of the formulated products were non-greasy and non-oily, homogeneously dispersed with a milky white finish and pH was discovered to be 5.6. Cariya papaya phytosomes had an average diameter of 198.09±0.04 nm while gingerol phytosomes had a diameter of 245.21±0.06 nm as determined by DLS with a negative zeta potential surface charge of -27.8 mV. The viscosity, transition temperature and absorbance time were found to be 2687cps, 25-350C and 1-2 min respectively. The activity of antioxidants rises as reaction time increases. When compared to rutin (standard), the formulation demonstrated (42.26%) strong total antioxidant and hydrogen peroxide scavenging properties. The microbiology test and stability tests indicated that the formulation was free of microorganisms and had good stability throughout the 3 months stability testing period, with no notable changes in physicochemical properties.

Keywords: Carica papaya phytosome, Gingerol phytosome, Aloe Vera, Face serum, Antioxidant, Antimicrobial, Moisturizing, Instant glow face serum.