Abstract

DESIGN AND IN-VITRO EVALUATION OF INCLUSION COMPLEX OF WATER INSOLUBLE DRUG GLIPIZIDE

Riyaz Ahmed Khan*, Md Majid Iqbal, Md Ateeq ur Rehman, Abedulla Khan Kayamkani

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Abstract

Solid dispersion (SD) systems have been extensively used to increase the dissolution and bioavailability of poorly water-soluble drugs. The purpose of the present investigation was to increase the solubility and dissolution rate of Glipizide by solid dispersions (SDs) and investigate them for in vitro dissolution study. Glipizide is an oral rapid and short acting anti diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation sulfonylureas are both more potent and have shorter half lives than the first generation sulfonylureas. The rationale of this study was to enhance the solubility & dissolution of the drug by preparing its complex with water soluble polymers such as PEG 4000 and PEG 6000 were selected as carriers. In the present study attempt has been made to prepare, formulate and characterize inclusion complexes of Glipizide with PEG 4000 and PEG 6000. The inclusion complexes were prepared by two methods viz. Physical method and Kneading method. The inclusion complex containing Glipizide: PEG 4000 and PEG 6000 were further formulated into Tablets by Direct Compression Technique using microcrystalline cellulose, Magnesium stearate and Aerosil. The prepared Tablets were characterized using FTIR and DSC and finally the prepared Tablets were Evaluated for various pharmaceutical characteristics viz. Hardness, % Friability, Weight Variation, Drug Content and In-vitro Dissolution profiles. The results of stability studies revealed no change in physical appearance, hardness, drug content and in vitro dissolution profiles, thus indicating that formulation was stable.

Keywords: Glipizide, PEG 4000, PEG 6000, Inclusion Complexation, Direct compressed Tablets, Microcrystalline cellulose.