Abstract

EVALUATION OF ANTI-ANXIETY ACTIVITY OF LAURUS NOBILIS ESSENTIAL OIL IN MICE

Sindhoora D.*, Ranjitha R. Nayak, Shanthi Maria Albubaque and Raksha B.

.

Abstract

Aim and Objective: The aim of this study is to evaluate anxiolytic activity of Laurus nobilis essential oil in experimental animals. Methods: The anxiolytic activity in mice was investigated by using Elevated plus maze (EPM) and Light and Dark Chamber (LDC), of Laurus nobilis essential oil (LNEO) were subjected for this study. The Swiss albino mice (22-27g) of either sex was divided into three groups of six animals each. Group I animals received Vehicle control (1% Gum acacia 10ml/kg) orally, Group II received Standard drug (Diazepam 1mg/kg) (ip) and Group III received LNEO – 200mg/kg (p.o) for 21 days. All animals will be pretreated for 20 days except diazepam treated animals. On 21st day, animals will be treated, 30 min before the evaluation. In EPM model, the parameters measured were; number of open arm entries, number of closed arm entries and time spent in open and closed arms and in LDC, the parameters measured were; number of crossings between light and dark side and time spent in light and dark side. Results: The administration of the dose (200mg/kg) of LNEO produced significant reduction of number of entries, time spent in closed arm and dark side respectively. And increase in number of entries and time spent in open arm and light side when compared with control and standard groups, thus Laurus nobilis essential oil shows the significant anti-anxiety activity.

Keywords: Anxiety, Laurus nobilis essential oil, EPM, Light and Dark Chamber.