SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CEFOPERAZONE SODIUM IN BULK AND PHARMACEUTICAL FORMULATIONS
K. Prabhavathi, N. Rami Reddy* and M. Mahammed Shafi
Abstract
A simple, sensitive, rapid and accurate colorimetric method has been
developed for the estimation of cefoperazone sodium in bulk and
pharmaceutical dosage forms. The proposed method was based on the
formation of chloroform extractable complex of cefoperazone sodium
with wool fast blue. The absorbance of the extractable ion pair
complex is measured at the wavelength of maximum absorbance 585
nm against the reagent blank. The results obtained with the proposed
method are in good agreement with labeled amounts, when marketed
pharmaceutical preparations are analyzed. Results obtained are
statistically validated and found to be reproducible.
Keywords: Spectrophotometry, Wool Fast Blue (WFB), cefoperazone sodium, Pharmaceutical formulation.
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