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Abstract

FORMULATION AND EVALUATION OF ANTIMALARIAL DRUGS SUPPOSITORIES

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman and

Abdul Basit Ahmed Al Ghoury

.

Abstract

Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artemisinin-based combination therapy (ACT) for malaria treatment have made a significant impact. Nevertheless, the development of resistance to the past and present anti-malarial drugs highlights the need for continued research to stay one-step ahead. The present study was aimed to formulate, evaluate and optimized of antimalarial drugs as suppository dosage forms different formula of Chloroquine phosphate, Pyrimethamine, Sulfadoxine a combination antimalarial containing the sulfonamide antibacterial Sulfadoxine and the antiparasitic Pyrimethamine, it is used to prevent and treat malaria. The rectal drug delivery can be alternative to oral route and convenient for infants, children and the elderly who find it difficult to swallow tablets. Alternative methods of Chloroquine phosphate administration such as rectal delivery to avoid the bitter taste and improve patient comfort and compliance. In the present study, attempt has been made to prepare drugs as suppository dosage forms of Chloroquine phosphate, Pyrimethamine, Sulfadoxine using suppository bases like Cocoa butter, Polyethylene glycol (PEG4000) and Witepsol H35 using different concentration of suppository bases the parameters of prepared suppository dosage forms melting point, weight variation, disintegration time, invitro dissolution release rate were evaluated. The present study found that among the all formulations F3(IV) Chloroquine phosphate formulation was found to be showed improved drug release characteristics. F3(IV), which consists of (Chloroquine phosphate and PEG4000 base), showed the best result in drug release for antimalarial drugs as suppository dosage forms.

Keywords: Suppositories, Chloroquine phosphate, Pyrimethamine, Sulfadoxine, Malaria.


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