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Abstract

A REVIEW ON ANTI-CANCER ACTIVITY OF AZADIRECTA INDICA (NEEM) IN ORAL CANCER

Juvansinh Chauhan*, Pooja Khanpara, Janaksinh Jadeja and Dr. Shital Faldu

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Abstract

Azadirachta indica, generally known as neem, is widely distributed in several semi-tropical and tropical nations, including India, Pakistan, and Bangladesh. For ages, the components derived from the neem plant have been utilized in traditional medicine to treat a variety of ailments, including cancer. The extracts of neem seeds, leaves, blossoms, and fruits have repeatedly demonstrated chemo preventive and antitumor activities in many forms of cancer. Azadirachtin and nimbolide are two of the few bioactive components of neem that have been thoroughly investigated, although more research on a wide range of other bioactive components is needed. The primary anticancer effects of neem components on malignant cells include cell growth inhibition, cell death induction, suppression of cancer angiogenesis, restoration of cellular reduction/oxidation (redox) balance, and stimulation of host immunological responses against tumor cells. Importantly, the anti-proliferative and apoptosis-inducing activities of neem components are tumor-specific, with no effect on normal cells. Furthermore, neem extracts make cancer cells more susceptible to immunotherapy and radiotherapy, as well as improve the efficacy of certain cancer chemotherapeutic drugs. This review highlights the most recent research on the oral anticancer properties of neem components and their potential impact on cancer incidence and treatment management.

Keywords: Azadirachta indica, Neem, Oral cancer, Chemoprevention, Anticancer.


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