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Abstract

CONCEPTUAL REVIEW ON ALZHEIMER’S DISEASE

Jilla Lavanya*, Banoth Deepika, Batchu Shivani and Bathula Niharika

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease. It is characterized by progressive cognitive deterioration together with declining activities of daily living and behavioral changes. It is the most common type of pre-senile and senile dementia. According to the world health organization (WHO), 5% of men and 6% of women of above of 60 years are affected with Alzheimer’s type dementia. Numerous herbs have been shown to improve brain function and may have a role to play in AD treatment. AD is considered as a multifactorial disease: two main hypotheses were proposed as a cause for AD, cholinergic and amyloid hypothesis. Additional, severe risk factors such as increasing age, genetic factors, plays a role in the disease. Currently available treatments i.e., acetylcholinesterase inhibitors (Rivastigmine, Galantamine, Donepezil) and N-methyl d-aspartate receptor antagonist (Memantine) contribute minimal impact on the disease and target late aspect of the disease. These drugs decelerate the progression of the disease, provide symptomatic relief but fail to achieve definite cure. Some dietary sources like omega-3 fatty acid, vitamin-E and vitamin-B and folate are used for the treatment of AD. The earliest symptoms can include problems with language, mood swings, loss of motivation, not managing self-care and behavioral issues. As a person’s condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to the death.

Keywords: Alzheimer’s Disease-(AD), beta-amyloid, tau protein, cholinergic.


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