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Abstract

FORMULATION AND CHARACTERIZATION OF ORALLY DISINTEGRATING FILM OF INDOMETHACIN

Pranay S. Bodkurwar*, Nagendra R., Venkatesh, K. Hanumanthachar Joshi

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Abstract

Technology advancements in recent years have made effective dose alternatives to the oral route for patients who are young, old, immobile, queasy, or unable to comply. Orally disintegrating film is a solid dosage form, which disintegrates or dissolves within 1 minute when placed in the mouth without drinking water or chewing. The oral film includes various ingredients for its formulation which includes polymers, active pharmaceutical ingredient, film stabilizing agents, sweeteners, flavors, colors, saliva stimulating agents, preservatives, surfactants, etc but the first and far most a very essential ingredient that helps in film formation is a Polymer. Orally disintegrating Film is prepared using hydrophilic polymers that rapidly dissolve on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made. For quickly disintegrating films, wafter-soluble polymers are utilized as film formers, water-soluble polymers give the films quick disintegration, a pleasant mouthfeel, and mechanical qualities. Oral films of Indomethacin were prepared by Solvent Casting method by using polymers like HPMC, propylene glycol, polyethylene glycol, citric acid, and saccharin sodium, total 9 formulations were done in which F3 was the most effective one and showed best results. Even Evaluations as thickness, weight variation, folding endurance, percentage elongation, tensile strength, drug content, SEM analysis, etc were done. F3 has shown less disintegration time of 20 seconds and 99% drug released within 3 minutes therefore, rapid drug release was achieved for immediate onset of action which is beneficial when compared to conventional tablet dosage form.

Keywords: 1) Oral disintegrating film 2) Oral dissolving film 3) Indomethacin 4) NSAID (Non-steroidal anti-inflammatory drugs) 5) Water-soluble polymers 6) Fast dissolving 7) Folding endurance 8) Tensile strength 9) SEM analysis 10) FTIR


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