Abstract

EVALUATION OF ANTI-ARTHRITIC ACTIVITY OF SIMAROUBA GLAUCA LEAVES EXTRACT

Dr. Hannah Elizabeth S.*, Joel Durairaj G., Dr. Channamma G. M., Dr. Reshma Karkera, Dr. D. Gnanasekaran and Dr. Shyam Kumar B.

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Abstract

The Ethanolic Simarouba glauca leaves extract was evaluated for its anti-arthritic activity. A preliminary phyto-chemical study of the extract for the presence of different phyto-constituents was carried out. In-vitro anti- arthritic activity of the Ethanolic Simarouba glauca leaves extract has been done by on Bovine serum albumin protein denaturation method and the inhibition of protein denaturation were evaluated in this study. The effect was compared with the standard drug Diclofenac sodium. The Ethanolic Simarouba glauca leaves extract significantly restored the altered arthritic activity when compared with standard values. It concludes that Simarouba glauca leaves posses anti-arthritic activity.

Keywords: Anti-arthritic activity, Simarouba glauca, Bovine serum albumin Protein, Phyto-constituents, Diclofenac sodium.