Abstract

DESIGN, DEVELOPMENT AND ASSESSMENT OF IN-VIVO ANTIINFLAMMATORY ACTIVITY OF AN ACECLOFENAC TOPICAL EMULGEL USING LEMONGRASS OIL

Akanksha Shinde*, Atish Velhal and Dr. Prakash Jadhav

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Abstract

Aceclofenac is a hydrophobic BCS class II non-steroidal antiinflammatory drug having potent analgesic, anti-inflammatory and antipyretic activity. This research is based on designing and developing a topical emulgel of aceclofenac using two different gelling polymers and lemongrass oil as a permeation enhancer. The research shows the impact of lemongrass oil as a permeation enhancer and analgesic. Six different emulgel formulations were prepared using different concentrations of gelling polymers and oil. Evaluation were carried out for various parameters like physical test, viscosity, pH, Spreadability, drug content, in-vitro drug release, in-vivo anti-inflammatory activity and skin irritation study. Carbopol 934 (2% gel) was the best polymer to formulate emulgel with 92.5 ± 0.76% of drug release than xanthan gum and combination gel formulations. Thus, the study reveals that this aceclofenac emulgel prepared using Carbopol gel and lemongrass oil improves the permeation through skin and it does not have any side effects or allergic symptoms like redness and swelling.

Keywords: Emulgel, Lemongrass oil, Gelling polymers, Carbopol 934.