Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF KETOPROFEN

Mohammed Hasan Faqera*, Venkatesh, Nagendra R., K. Hanumanthachar Joshi

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Abstract

The main aim of present work was to formulate and evaluate sustain release matrix tablets of ketoprofen, “an anti-inflammation”. Sustain release formulation are those which delivers the drug locally or systemically at a predetermined rate for a fixed period of time. The matrix tablet was prepared by direct compression method using by various concentration of HPMC and TRAGACANTH with combination of various release retardant polymer. The powder mixtures were subjected to various pre-compression parameters such as angle of repose, bulk density, tapped density and Carr‟s index shows satisfactory result and the compressed tablets are evaluated for postcompression parameters such as weight variation, thickness, hardness, friability, drug content, in-vitro dissolution and stability studies. Invitro dissolution studies were carried out for 24 hours using 0.1 N HCL for first 2 hours and pH 6.8 phosphate buffer for 24 hours and the result showed that formulations F4 and F7 showed good dissolution profile to control the drug release respectively. Formulation containing higher concentration of HPMC and TRAGACANTH along with polymers sustained the drug release for the period of 24 hours. The compatibility of the drug, polymers and other excipients were determined by FT-IR Spectroscopy. Results showed that the drug was compatible with polymers and other excipients. The release data was fitted to various mathematical models such as Zero-order, First- order, Higuchi equation and Korsmeyer- Peppas model to evaluate the kinetics and the drug release. The drug release followed first order and the mechanism was found to be non-Fickian. The stability studies were carried out for 3 months and result indicates that the selected formulations (F4 and F7) were stable.

Keywords: 1) Oral administration 2) Sustained Release 3)Controlled release 4) Receptor targeting 5) NSAID (Non-steroidal anti-inflammatory drugs) 6) KETOPROFEN 7) Polymers 8) FTIR