Abstract

BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM

Anjali A. Gupta*, Pooja R. Hatwar, Dr. R. L. Bakal, Dr. N. B. Kohale, A. N. Motwani

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Abstract

Mucoadhesive drug delivery systems are specialized formulations designed to adhere to the mucosal surfaces in the body, such as the oral cavity, nasal cavity, gastrointestinal tract, and vaginal canal. These systems aim to enhance the therapeutic efficacy of drugs by prolonging their contact time with the mucosa, improving drug absorption, and providing localized drug delivery. Mucoadhesion refers to the adhesion of a material to the mucus layer. Mucoadhesive drug delivery systems utilize various polymers and bioadhesive substances to achieve prolonged drug residence at the site of application. The key benefits include enhanced drug absorption, reduced dosing frequency, improved therapeutic efficacy, and targeted delivery to specific mucosal tissues. Buccal Mucoadhesive Drug Delivery System are specifically designed to adhere to the buccal mucosa (inner lining of the cheek) for targeted drug delivery and enhanced therapeutic efficacy. Buccal mucoadhesive drug delivery system utilize bioadhesive polymers and other excipients to prolong the contact time of drugs with the buccal mucosa. This allows for localized drug delivery, improved drug absorption, reduced dosing frequency, and avoidance of first-pass metabolism. Buccal mucoadhesive drug delivery system have diverse applications. They are used for local treatment of oral diseases like oral mucositis, periodontal diseases, and aphthous ulcers. Additionally, they are employed for systemic delivery of drugs, including peptides, hormones, analgesics, and antiemetics.

Keywords: Mucoadhesive DRUG delivery system; theories of mucoadesion factor affecting buccal drug delivery system; polymers.