Abstract

POTENTIAL TARGETS AGAINST LEPROSY – A PHARMACOLOGICAL REVIEW

Jagbir Singh*¹, Sunil Verma²

Abstract

Leprosy is a non-fatal, chronic and debilitating infectious disease caused by Mycobacterium leprae. Leprosy is a spectral disease in which an inverse correlation exists between the bacterial index and cell mediated immunity. In Patients having leprosy, skin lesions become acutely inflamed and edematous. The plaques are painless to touch or pinprick and there are swelling of the nerves in the fibro-osseous tunnels under the surface of the skin. Diagnosis remains a challenge for physicians because the incubation period of leprosy is uniquely long among bacterial diseases and varies from a month to over 40 years. Since therapies (e.g. Multi Drug Therapy) are available for leprosy but due to some serious adverse effects and emergence of multi drug resistance there is need of potential drug targets and some genes identified as drugable targets with the help of insilico similarity search algorithms against mycobacterium. leprae.

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