Abstract

EVALUATION OF THE ANTIHYPERTENSIVE EFFECT OF THE AQUEOUS EXTRACT OF THE ROOTS OF DISSOTIS BRAZZEÏ COGN. AT THE WISTAR RAT

*Peneme B. M. L., Ondélé R., Akassa H., Ngono M. H., Etou Ossibi A. W. and Abena A. A.

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Abstract

Dissotis brazzeï Cogn is a plant frequently used by traditional Congolese medicine against high blood pressure. This study aims to evaluate the antihypertensive effect of the aqueous extract of the roots of Dissotis brazzeï Cogn in wistar rats. The acute toxicity of the extract was previously studied in mice. Therefore, 25 male Wistar rats were divided into five (5) groups of five (5) rats each and treated for 21 days. These groups were treated as follow: group 1 (distilled water); group 2 (an 8% wt NaCl solution), group 3 (NaCl 8% immediately followed by furosemide at 20 mg/kg; b.w.), group 4 and 5 (each of 8% NaCl followed immediately by the aqueous extract of the roots of Dissotis brazzeï Cogn. at respective doses of 250 and 500mg/Kg. Pharmacological tests showed a significant reduction in blood pressure and heart rate of rats made hypertensive by 8% NaCl. In addition, the hematological and lipid parameters evaluated showed a significant modification of parameters such as triglycerides and red blood cells. This extract did not modify the weight of noble organs at the used doses. Thus, the diuretic and antihypertensive effects of this extract would be justified by its secondary metabolites such as flavonoids and tannins.

Keywords: Antihypertensive effect, Dissotis brazzeï Cogn., Rats, Nacl, Blood pressure.