Abstract

IMPROVEMENT OF DISSOLUTION AND ANTI INFLAMMATORY ACTIVITY TENOXICAM BY SPHERICAL AGGLOMEARATION

Alladi Saritha* and Nalini Shastri

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Abstract

Spherical agglomerates of tenoxicam were prepared by the neutralization method with additives (polyethylene glycol 6000, polyvinyl pyrrolidone, and HPMC) using di ethyl ether as a bridging liquid. Prepared agglomerates were evaluated for solubility, dissolution rate and pharmaco dynamic activity, and characterized by SEM, XRPD, DSC and FTIR spectroscopy. Particle size, flowability, solubility, dissolution rate and anti inflammatory activity of plain agglomerates and agglomerates with additives were advantageously improved compared with tenoxicam. XRPD and DSC studies indicated polymorphic transition of tenoxicam during recrystallization but this was not associated with any chemical transition, as indicated by FTIR spectra, well supported by stability studies. Thus spherical crystallization by neutralization method the with selected additives is a satisfactory method for direct tableting of tenoxicam giving improved dissolution rate.

Keywords: XRPD and DSC studies indicated polymorphic transition of tenoxicam during recrystallization but this was not associated with any chemical transition, as indicated by FTIR spectra, well supported by stability studies.