Abstract

AN EXPERIMENTAL STUDY TO EVALUATE THE HAEMATINIC EFFECT OF INDIGENEOUS DRUG FORMULATION IN PHENYLHYDRAZINE INDUCED ANEMIC PREGNANT WISTAR ALBINO RATS

Neethu*, Vidya Ballal, Mamatha K. V. and Sudakar Bhat

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Abstract

Pregnancy is a physiological process, associated with certain adaptation, which when not taken care in the antenatal period can lead to anemia in pregnancy. Iron deficiency anemia is the most common type of anemia met in obstetric practice. About 4 to 16% of maternal deaths are due to anemia. It also increases the maternal morbidity, fetal and neonatal mortality and morbidity significantly. In Ayurveda this condition is considered as Garbhini Pandu. The rasa and rakta of the mother are carried to the fetus for its proper growth and development. If not, it leads to rasa dhatu kshaya in garbhini which finally leads to Garbhini Pandu. Ayurveda highlights the contradiction of shodana in pregnant ladies, hence shamana chikitsa can be followed judiciously. Contemplating the essentiality to use a drug that is beneficial in Garbhini pandu, safe and conducive during pregnancy, certain indigeneous drugs like Agasthya, Amalaki, Draksha, Musta, Pippali, Sigru, Shuddha Kasisa and bhavana dravyas like Dadima, Bhringaraja and Mandukaparni has taken. So an experimental study is essential prior to the clinical study inorder to understand the toxic effect and haematinic effect, owing to its properties like raktavardhaka, yakrututtejaka, deepana, medhya, rasayana and krimigna. The selected animal was grouped into 5 groups with 6 animals each. The animal experiment showed that the indigeneous drug formulation is found efficacious in increasing the hemoglobin concentration and serum iron, and no toxic effects have been observed throughout the duration of the study.

Keywords: Anemia, Hemoglobin, Indigeneous drug formulation, Serum iron.