Abstract

FORMULATION AND EVALUATION OF METRONIDAZOLE LOADED ETHOSOMES FOR ANTIBACTERIAL ACTIVITY

Muskan Lashkari*, Dr. Kaushelendra Mishra, Priyanka Namdeo and Dr. Parul Mehta

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Abstract

Ethosomes entrapping metronidazole were prepared using cold method and the effect of varying concentration of ethanol was considered for obtaining an optimized formulation. Lecithin (2%w/w) was used as the phospholipid to provide the structure to vesicles and propylene glycol (10%) was used as the permeating agent. The vesicles were found to be of spherical to irregular shape ranged from 3.248 ± 0.733μm to 6.032 ± 2.883 μm in size. The drug entrapment in the ethosomes was studied by analyzing the amount of drug after breaking the vesicles with Triton X100 and it was found that the maximum entrapment efficiency was found to 94.43% for formulation F5 and minimum 86.24% for formulation F1, respectively. The in vitro release study suggested that the maximum amount of drug released from the ethosome was 97.4% for F1 while the least release was 91.2% from F5 in 12 h.

Keywords: Ethosome, Metronidazole, Entrapment, Release, Lecithin.