Abstract

COMPARATIVE PHARMACEUTICAL ANALYTICAL STUDY OF MADANODAYA RASA PREPARED BY CONVENTIONAL AND CONTEMPORARY METHOD

Manjusha B.*, Dr. S. A. Doddamani, Dr. Surekha S. Medikeri

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Abstract

Introduction: Madanodaya Rasa is a Sardha Samaguna Bahirdhuma Kupipakwa Rasayana which is mentioned in Rasa Manjari having vrishya property. Kajjali is prepared by adding Shudha Hingulotha Parada and Shudha Gandhaka in the ratio of 1:1½ and the bhavana dravya is Rakta Kamala pushpa swarasa. Aim and Objective: The present study was carried out to compare the pharmaceutical preparation by Valuka yantra method and VMF method. Both these samples were subjected to XRD, FTIR and SEM-EDS analysis. Materials and Methods: Purified Hingulotha Parada and purified Gandhaka in the ratio 1:1 was utilized to prepare Kajjali, then levigated with Rakta Kamala pushpa swarasa Then ½ part Shudha Gandhaka was added and triturated till all moisture content evaporated. The Kajjali was processed by Valuka yantra and VMF. Physico-chemical and Instrumental analysis were carried out for both the samples. Results and Conclusion: MDR was prepared in 36 hrs. and 22 hrs. with Valuka yantra and VMF method and yield was 10.66% and 28% respectively. XRD report revealed Cubic crystalline structure with HgS compound in MDR Kajjali and showed Hexagonal Crystalline structure with Mercury Sulphide compound in MDR. In SEM report smallest particle size of MDR prepared by Valuka yantra method (Batch-I) is 18.46 nm and by VMF method (Batch-II)is 30.47 nm. EDS report shows that MDR prepared by Batch-I has Hg (84.55 %) and S (15.45%) and MDR prepared by Batch-II has Hg (84.64 %) and S (15.36%) as major elements and C and O₂ as trace elements. FTIR report revealed the presence of organic functional groups. Conclusion: VMF is more convenient than the Valuka yantra.

Keywords: Kupipakwa Rasayana, Madanodaya Rasa, Valuka yantra, VMF, XRD, SEM-EDS, FTIR, Vrishya.