Abstract

LIPID DRUG DELIVERY SYSTEMS FOR BIOAVAILABILITY IMPROVEMENT OF POORLY WATER SOLUBLE ANTIHYPERTENSIVE MEDICATIONS

Yenge Vaishnavi*, Nandini Mane, Sonali Waghmare, Akanksha Yedale, Shivani Tomar, Mr. Joshi D. A.

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Abstract

The majority of drugs used to treat different ailments are taken orally and delivered through a traditional delivery. Because of its low water solubility, chemical stability, and pre-systemic metabolism, oral administration has a low bioavailability. In terms of solubility and bioavailability, poorly water-soluble drugs pose a challenge to formulation experts. One of the new innovations intended to address such issues is lipid-based drug delivery system (LBDDS). Higher solubilization and absorption can be achieved by encapsulating or solubilizing the medicine in lipid excipients, resulting in enhanced bioavailability. We attempt to explore the different innovative delivery aspects created for the increase of oral bioavailability of poorly watersoluble medicines in this review. This review is mainly focused on the formulation approach of the lipid-based drug delivery system along with its characterization. The review also focuses on the practical guidelines to design formulations and potential applications of the lipid-based drug delivery system.

Keywords: Lipid-based drug delivery system, Lipid, Bioavailability, Solubility.