Abstract

IN-VITRO COMPARATIVE STUDY OF GENERIC VS BRANDED TABLETS – A REVIEW

Vetrivel D.*, Dr. K. B. Ilango, Bhuvaneswari S., Gomathi P. and Kowsalya Devi M., Madhan Raj M. and Surenthiran M.

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Abstract

Generic medications have been shown to be therapeutically equivalent to their branded counterparts through in-vitro comparative studies. This means that they contain identical quantities of the active ingredient and produce comparable clinical effects in patients. To assess the quality of generic and branded tablets of a particular medication, we employed in-vitro methods. A series of in-vitro tests, including general appearance, thickness, diameter, hardness, friability, weight variation, content uniformity, disintegration, and dissolution tests, were performed on both generic and branded tablets of the same medication. The results of these tests were evaluated against the standards established in the relevant pharmacopoeia. If both sets of data corresponded, it served as evidence of the quality, therapeutic efficacy, and safety of generic drugs.

Keywords: Generic drug, Branded drug, comparative study, Content uniformity, Disintegration, In-vitro drug release.