Abstract

TRANSFEROSOMES: AN APPROACH TO IMPROVE DRUG ACTIVITY

Shafiya Samreen, Venu Madhav Katla* and Somnath De

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Abstract

Achieving a Successful therapeutic intervention can be challenging in numerous cases, Factors like First-pass metabolism in the liver, the onset Undesirable side effects, reluctance towards, Invasive medical procedures and insufficient Adherence to medical recommendations by the patient. all contribute to the complexity of the process. Consequently, extensive research and development efforts have been dedicated to addressing challenges from previous decades. A particularly encouraging solution involves the adoption of transdermal drug delivery systems, given their minimally invasive nature and the advantage of bypassing first-pass metabolism. In the 1990s, a novel carrier system known as transferosomes was introduced. Comprising phospholipids and an edge activator—a membrane-softening agent— these transferosomes exhibit an ultra-deformable property. Upon entering skin pores, transferosomes demonstrate the ability to modify the flexibility of their cell membranes, enabling Facilitate their passage through the skin pores naturally. This is also said to be self-optimizing deformability. Effortlessly traversing even, the narrowest pores, refine these lipid aggregates with inherent self-optimization and remarkable deformability have been widely employed in extensive preclinical testing. Furthermore, their utilization extends to Phase I and Phase II clinical studies, demonstrating effectiveness In the transcutaneous administration of peptides and proteins, as well as in sustaining the release of desired therapeutic agents.

Keywords: Transferosomes, ultra-deformable vesicles, first phase metabolism.